ASEA Antioxidant Up-Regulation

Oxidative stress is an imbalance between the
production of free radicals and the ability of the body to
counteract or detoxify their harmful effects at a cellular
level. ASEA commissioned Pacific Northwest National
Laboratory (PNNL) to determine if exposure to ASEA
Redox Supplement activated the cell nucleus to call for
increased production of antioxidants, such as glutathione
peroxidase (GPx).

Study Protocol

Researchers exposed human endothelial cells to
either ASEA Redox Supplement or an inert phosphate
buffer solution (PBS). Standard western blot analysis
was used to determine if exposure to ASEA Redox
Supplement activated cell nuclei to increase production
of antioxidants such as GPx, an essential enzyme in
cellular antioxidant defense systems. The concentration
of messengers in the nucleus that activates increase of
antioxidants was also measured in human endothelial
cells and compared to cells not exposed to the
redox supplement.

The movement of the agents into the nucleus can be
seen with certain dyes under a microscope and offers a
way to see the call for an increase of antioxidants.
Since the production of antioxidants can also increase
by exposure of the cells to low levels of inflammatory
toxins, tests were performed to ensure that ASEA Redox
Supplement was not provoking the cells to undergo this
low-level inflammatory or toxic response.

Results Summary

Verification by the western blot analysis showed clear responses in the increase of antioxidants upon exposure to the redox supplement in comparison to the saline control. This effect was temporary, lasting only about 120 minutes but was clearly visible.

Researchers indicate that the most impressive result of this evaluation is that exposure to ASEA Redox Supplement at any concentration did not invoke an inflammatory response but did invoke an antioxidant increase. Stimulating the production of antioxidants without stimulation of low-level inflammation is very rare

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